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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Major Concerns When Blood Group Of Mother Do Not Match With Baby?

Prior to the development of Rhogam, a woman with blood type O- giving birth to a baby with blood type A+ had a 2% chance of developing an immune response and producing anti-Rh antibodies. A woman with blood type A- giving birth to a baby with blood type O+ had a 16% chance of immune response. (8 pts) pg 198
A.    Why do you think there such a large difference in risk?
B.   Why are the risks not higher In either case?
Mon, 7 Jul 2014
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Hematologist,  's  Response
hi, friend, there are two types of incompatibility. one is ABO incompatibility. and one is Rh incompatibility. Rh negative mother give birth to the Rh positive baby. at that time risk is due to Baby's RBCs come in contact with maternal blood and produce antibody against that. that antibody cross the placenta and goes in to baby's blood stream and destruct baby's RBCs. this is the cause for Rh incompatibility. now Same can occurs for the ABO but good thing is that ABO antibody are IgM type. so it can not cross the placenta and same thing not happens frequently but rarely it may be of IgG type at that time it produce incompatibility. so the difference in the risk is due to that. and not high risk in either cases are due to the reason, the reason is that blood of maternal and fetus run in two separate circulation with the placental barrier. so Bleeding in antenatal period or at the time of delivery contact may occurs. otherwise this phenomena is out of question. that's why risk is low.
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What Are The Major Concerns When Blood Group Of Mother Do Not Match With Baby?

hi, friend, there are two types of incompatibility. one is ABO incompatibility. and one is Rh incompatibility. Rh negative mother give birth to the Rh positive baby. at that time risk is due to Baby s RBCs come in contact with maternal blood and produce antibody against that. that antibody cross the placenta and goes in to baby s blood stream and destruct baby s RBCs. this is the cause for Rh incompatibility. now Same can occurs for the ABO but good thing is that ABO antibody are IgM type. so it can not cross the placenta and same thing not happens frequently but rarely it may be of IgG type at that time it produce incompatibility. so the difference in the risk is due to that. and not high risk in either cases are due to the reason, the reason is that blood of maternal and fetus run in two separate circulation with the placental barrier. so Bleeding in antenatal period or at the time of delivery contact may occurs. otherwise this phenomena is out of question. that s why risk is low.