Hi I am Dr.kadhir, To answer you first question, There are quite a number of conditions which presents with constipation, starting from a small ulcer in the anal region to some serious bowel diseases but the most common one being habitual constipation . My advice is to first rule out all other serious causes, then treat for conditions like habitual constipation. Cremaffin is liquid paraffin and magnesium , it definitely interferes in the absorption of fat soluble vitamins like Vit A , D , E, K on prolonged use.. Recent drugs used are: Movicol (macrogol or polyethylene glycol ) is an laxative which softens the stools by increasing its water content . Its quite safe and effective only when used properly (adequate dose and method). Method of preparing the drug and number of sachets are more important. The side effects are quite rare, mainly due to dehydration , loss of electrolytes and over dose. Movicol can be used for short term and then proper fiber diet (fruits and vegetables), adequate water and lactulose can be used. Lactulose dose can be increased cautiously ( to avoid major side effects) till satisfactory response is obtained. Then it is safe to slowly stop these drugs and focus more on diet therapy. All these drugs have their own side effects. When on these drugs, regular follow up is necessary to monitor for side effects. Answer for the second question, Avomine is promethazine tablets , they are effective for travel sickness.The use of this medicine may lead to drowsiness and impaired concentration so it is better to avoid driving. Thank you for the consultation in health care magic