Hello Ved Prakash..
Thanks for sharing your query here.
Topicals in the form of Propysalic ointment can be used if involvement is up to a certain percentage of body area by Psoriasis
. Beyond a specific limit, you will need oral /injectable therapy which unfortunately has the potential if side-effects ,if not monitored closely. For a chronic condition like psoriasis , treatment regimen is modified according to the severity of disease ,which might be different in different times of the year.So, a close follow-up with your dermatologist
is important for optimum result and achieving a remission.
For the methotrexate
that you are using , side effects like nausea
may be dose-dependent.Therefore, several physicians consider adjusting the dose or modifying the mode of intake to eliminate the problem.The total dose of Methotrexate can be divided & taken over 2 days every week; or you may take it at bed-time ,if taking during the day causes nausea; it can also be take after food ,instead of before .
Still if nausea persists , you may consider switching over to injectable Methotrexate once a week .
Several other drugs are available for treatment in psoriasis and include, Retinoids
, Cyclosporin, PUVA therapy
I would advise you to discuss these with your dermatologist and continue the therapy.Hope the is helpful