Hi Pantoprazole belongs to proton pump inhibitor group of medications, used for acid suppression. Antacid preparations such as pantoprazole work by suppressing the acid-mediated breakdown of proteins. This leads to an elevated risk of developing food and drug allergies due to undigested proteins passing into the gastrointestinal tract where sensitization occurs. It is unclear whether this risk occurs with short-term or only long-term use. Common Gastrointestinal: Abdominal pain (3%), diarrhea (4%), flatulence (4%) Neurologic: Headache (5%) Serious Gastrointestinal: Atrophic gastritis, clostridium difficile diarrhea Hematologic: Thrombocytopenia (less than 1%) Immunologic: Stevens-Johnson syndrome, toxic epidermal necrolysis Musculoskeletal: Muscle disorders, bone fracture, osteoporosis-related, hip fracture, rhabdomyolysis Renal: Interstitial nephritis (rare) As you can see, these drugs are good for short term treatment ,long term use can lead to side effects ,some of which are serious. Hope it helps.