Hello and welcome to Healthcare Magic. Thanks for your query. I understand that you are quite distressed by the fact that your urine drug screen has come positive when you are sure that you haven t abused any drugs. Usually urine drug tests are reliable and have a high degree of specificity - which means that they are able to correctly detect the specific drug which is being screened for. However, very rarely, there can be false positive tests. The most common cause for a false positive test is ingestion of medication or substances which have a similar molecular structure as the drug being screened for. Regarding opiates, certain OTC medication like cough syrups or sleep formulas or certain pain medication or even certain herbal extracts can possibly cause a false positive result. You have not mentioned what prescription medication you are taking, so I will not be able to comment whether they can possibly cause a false positive drug screen. Having a high BP doesnt necessarily imply that it is due to the effect of the drugs. You will need regular BP monitoring to see if you have hypertension and if you need to be treated for the same. I would suggest that you discuss about the drug tests with your doctor and also clarify regarding your health issues. It may also be a good idea to take the support of your family members and consider what resources and options are available to tackle the current situation. Wish you all the best. Regards, Dr. Jonas Sundarakumar Consultant Psychiatrist