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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Unable To Sit On The Floor And Stand Without Support, Development Delay. Taking Encorate 300. Side Effects?

My daughter is taking Encorate 300 from the past 2 years. Recently she is unable to sit on the floor & stand without a support (earlier this problem was not there). She is now 9 years old & also a Development delay child. When we consulted a doctor about this, he advised that this is due to the side effect of the Encorate tablet & suggested to take some Calcium tablets. Need to know more about this.
Mon, 5 Nov 2012
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General & Family Physician,  's  Response
Hi,
Long-term use of encorate(valproate) has been linked to bone loss. Taking supplements of both calcium and vitamin D may help to prevent bone loss. Patients who have taken valproic acid or other forms of valproate for more than 5 years may be advised to have a bone density test. If the test shows significant thinning of the bones, referral to a bone metabolism specialist may be indicated.Currently, there are no formal recommendations regarding the prevention, identification, and treatment of bone disease in patients using anticonvulsants .Moderate sunlight exposure, weight bearing exercise,avoidance of other drugs that may deplete bone may help in preventing bone loss. Calcium and Vit D3 oral tablet should be taken to minimise valproate induced osteopenia. You did not mention about the cause for which valproate was advised. Don't make an attempt to stop valproate without consulting your doctor because that may precipitate seizure in an epileptic child.But an attempt can be tried if your child was free of symptoms for a long time after taking encorate. Don't make an attempt yourself. Take the help of a specialist. Hope, I answered your queries.
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Unable To Sit On The Floor And Stand Without Support, Development Delay. Taking Encorate 300. Side Effects?

Hi, Long-term use of encorate(valproate) has been linked to bone loss. Taking supplements of both calcium and vitamin D may help to prevent bone loss. Patients who have taken valproic acid or other forms of valproate for more than 5 years may be advised to have a bone density test. If the test shows significant thinning of the bones, referral to a bone metabolism specialist may be indicated.Currently, there are no formal recommendations regarding the prevention, identification, and treatment of bone disease in patients using anticonvulsants .Moderate sunlight exposure, weight bearing exercise,avoidance of other drugs that may deplete bone may help in preventing bone loss. Calcium and Vit D3 oral tablet should be taken to minimise valproate induced osteopenia. You did not mention about the cause for which valproate was advised. Don t make an attempt to stop valproate without consulting your doctor because that may precipitate seizure in an epileptic child.But an attempt can be tried if your child was free of symptoms for a long time after taking encorate. Don t make an attempt yourself. Take the help of a specialist. Hope, I answered your queries. Thanks.