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Taking methadone, xanax and tofranil. Scheduled for colonoscopy. Will anesthetic have interaction with my medications. Suffering from anxiety

I am a methadone maitenance person who has a colonoscopy scheduled tomorrow. I have informed my doctor that I am on 50 mgs of methadone a day. The anesthetic that is being used is propofol . I am also on 50mgs Tofranil(imipram),1 and a half mg of xanax . I have been searching the web for answers but to no avail.. Is it safe for propofol + methadone + xanax to be mixed? I am having severe anxiety with this issue. I was afraid to ask my gastro b/c I don t know him and don t want hoim to think I am a nervous nellie.
Asked On : Fri, 6 Jul 2012
Answers:  1 Views:  281
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General & Family Physician 's  Response
Hello and thanks for your query.

I shall make an effort to provide you with good professional recommendations specific to your questions.

Moderate ranking of interactions. Propofol and Methadone : Increased effects on breathing, heart rate, blood pressure, and sedation. The same with Propofol and Alprazolam. Your surgeon should be informed of same. They will take precautions during surgery.

Let me know if I have missed out any other concern in your question.

Yet again, I duly appreciate your query to me, I do hope that you have found something useful to help you and I shall be glad to answer any further apprehensions.


Dr Sujeet N Charugulla,
Consultant Physician.

Answered: Wed, 7 Aug 2013
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