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Cymbalta belongs to SNRI group and it has no effect on weight. While almost all of TCAs will have weight gain as side effect but they cause sedation so help in sleep. And combination will definitely result in Serotonin Syndrome. Other option you can discuss with your Psychiatrist regarding addition of some sedative drug for sleep for some time and continue taking Duloxetine for your problem of fibromyalgia.

Thanks
Dr. Seikhoo Bishnoi, MD

Hi there, thanks for asking. It is a very good question. Managing fibromyalgia without managing sleep problem is not possible. As you mentioned cymbalta can cause sleep problem in many people. There are some medications from the class of tricyclic antidepressant which cause no weight gain or minimal gain compared to their similar drugs. Some of them like desipramine or imipramine, etc cause less or no weight gain. You can ask your doctor more about them. I wish you a good health.

Hello,
Thanks for choosing health care magic for posting your query.
Amitryptilline is a good drug for fibromyalgia and non-specific pains. Duloxetine (Cymbalta) is also supposed to be meant for the same. However if were showing improvement with Amitryptylline , you should continue it. All the tri cyclic drugs have more or less the same potency to cause weight gain.
You should start exercising regularly and start eating healthy food. Avoid eating out and eating fatty food.
Hope I am able to answer your concerns.
If you have any further query, I would be glad to help you.
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Wish you good health,
Dr. Srikanth Reddy M.D.