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Taking Telma and Cardace for high blood pressure. Side effects?

I am paul rana from Nepal. I have been taking some different kind of medicine to lower down my bloodpressure it was once 170/110, So now I am visiting to Sanjay Gandhi Post graduate institute of medical science in regular basis. Now I am taking two medicines: telma 40 once a day and Cardace 2.5 twice a day. I want to know more about side effects of these two medicines. Please guide me and advice. My email address is YYYY@YYYY Thanking you,
Asked On : Thu, 28 Mar 2013
Answers:  2 Views:  456
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Cardiologist 's  Response
telma is ARB cardace is ace inhibitor,
Avoid prescribing an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin receptor blocker (ARB) for patients at high risk of vascular events or renal dysfunction. The combination does not reduce poor outcomes, and leads to more adverse drug-related events than an ACE inhibitor or ARB alone
combination of these ( ace + arb) leads to renal dysfunction, increase of serum potassium, hypotension

Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET) found that dual RAS blockade was no more beneficial than monotherapy with an ACE inhibitor or an ARB in preventing serious outcomes in patients with known vascular disease or diabetes with end-organ damage. Furthermore, patients on dual RAS blockade had higher rates of renal insufficiency, hyperkalemia, and hypotension.

side effect of cardace -Hypotension, renal impairment, angioedema, chronic cough, hyperkalemia.
Nausea, vomiting, diarrhoea, dizziness, fatigue, headache, abdominal pain
side effect of telma - back pains, inflammation of the sinuses, diarrhea, and infections of the respiratory tube,Headache, dizziness , renal dysfunction, hyperkalemia

you should stop cardace and take telma-h instead of telma , add amtas 5 mg
your bp will be controled
Answered: Fri, 29 Mar 2013
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Internal Medicine Specialist Dr. Maruti Karale's  Response
thanks for being with HCM.

Here i have mentioned some common side effects of telmisartan and cardace (Ramipril).

Common side effects of telmisartan include :
Kidney function impairment
Dizziness,lightheadedness, or faintness upon rising
muscle cramps or weakness,
irregular heartbeat
Cough, though less commonly than with cardace.

Common side effects of cardace include:
headache, dizziness,
nausea, and
renal impairment

As telmisartan and cardace has common side effects and both of them has same mechanism of action hence these two drugs should be used in combination.If these two drugs are to be used in combination there should be strict monitoring of electrolytes and renal function.

Hope this could help you.

Take care.
Answered: Fri, 29 Mar 2013
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