Dear Seroquel XR (quetiapine) is an oral antipsychotic drug prescribed for the treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder. Frequent adverse side effects of Seroquel XR include headache, agitation, dizziness, drowsiness, weight gain, and stomach upset. More severe side effects of Seroquel XR include orthostatic hypotension, seizures, hypothyroidism, tardive dyskinesia, neuroleptic malignant syndrome, high blood cholesterol and triglycerides levels. There are several drugs which has adverse side effects if taken along with Seroquel. In your wife s case, the physician is the best judge. The report that one of the cause is seroquel, may be superficial. Believe your physician, after all, we are not the creator or eliminator of life.