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TB meningitis, taking medicines post surgery, recent scan features suggestive of gliosis. What could this be?

hello sir... i am a tb menigitis patient... i had surgery on last year and i am using akt4, oflox,claribid(clarithromycin500mg),benadon40mg from last 1year. recently i had and ct scan of brain. the report says status post carnitomy in left fronto temporo pariental region. I11 defined csf density in left temporal region-suggestive of gliosis .can i know whats it curing..
Asked On : Wed, 24 Oct 2012
Answers:  2 Views:  79
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Neurologist 's  Response
Hi ,
It seems that you had tuberculous meningitis with tubercular abcess in left temporal region ,for which Left fronto temporal craniotony with evacuation of abcess might be done. So once operation is done part of brain tissue would be removed.Like any wound in body which when heals will left with scar ,it is the same thing in brain which is called as gliosis.

Gliosis is a process of scarring in the central nervous system. It results from the proliferation of astrocytes in an injured or diseased part of the brain, causing the formation of a fibrous glial scar. Although they are a necessary element to injury recovery, both the accumulation of glial cells and subsequent scarring are important markers of neurological damage.Scar cannot be removed ,it produce headache and seizure
Answered: Fri, 3 May 2013
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Pathologist and Microbiologist Dr. Shailja Puri 's  Response
Hello and welcome to HCM
Inorder to understand the meaning of term 'gliosis', first you need to know a bit about the normal cells present in the brain.
the cells of brain are:
1. Neurons which conduct the signals to and from the brain
2. Glial cells: These are supporting cells which provide support, synthesize myelin and secrete CSF in the ventricles of the brain
3. Macrophages which clear any kind of infectious and pathological material from the brain parenchyma

In any kind of disease process like infection, inflammation, degeneration there is increased proiferation of the glial cells as a repair and regenerative process.

Since, you have had TB meningities and subsequent surgery gliosis is a normal finding.

Thanks and take care
Dr Shailja P Wahal
Answered: Wed, 24 Oct 2012
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