tablet has four anti-tuberculosis
drug of which Rifampicin
has to be taken in empty stomach.
2. The capsule in AKT4 is Rifampicin and you need to take that drug 30 min before breakfast and rest of the medications after breakfast any time within say an hour. This is to increase the absorption rate of the drug from your intestine and to decrease few gastro-intestinal side effects also.
3. Missing even a single dose of ATT is not good, but if it happened don't double the dose next day. Doubling the dose may exceed your daily maximum dosage of the drug leading to more side-effects. Its also not advisable to take few tablets in afternoon or night, because the concentration of the drug in blood may vary, which might not be effective against TB bug. So as far as possible stick to taking tablet in breakfast every day.