what do you do when you have had severe treatment-resistant depression for about 15 years. we have honestly tried every combo you can imagine and then some.... I did ECT, 10 sessions and might as well have stayed home and taken Flintstone Vitamins. Not 1 clinical trial will take me because they say the chances of me getting better are minimal and they need success stories. Oh yeah, there was one Dr. that said he would give DBS a try, no thanks. So I inhale and exhale and the days go by, with no joy or happiness. At this point I think my dr. who is wonderful, is trying to buy some more time hoping something will come our way that just might work. I live in Richmond, Va and have seen all of the top Doctors for 2nd, 3rd and 4th opinions and they all agree I have done all there is to do. I have zero hope and would appreciate any suggestions. Thanks a lot!