Hello. Thanks for writing to us at healthcaremagic I will keep a possibility of dyshidrotic eczema/pompholyx, which presents as itchy fluid filled blisters/vesicles classically along the sides of the fingers and toes but also on the palms and soles. Those individuals who are allergic/atopic have higher chances of developing pompholyx and it is believed to be a type of allergic reaction. The lesions of pompholyx can develop as an allergy to metal salts such as nickel, cobalt, chromium. Nickel is usually present in ornaments or ingested in food. Exposure to other salts may be occupational. Other possible allergens include certain topical antibiotics e.g neomycin, allergens Or chemicals such as perfumes and irritants such as detergents etc. Treatment includes topical application of a potent topical steroid + antibiotic cream twice daily for 2 weeks. An OTC antihistamine e.g cetrizine would help in providing symptomatic relief from itching. I would suggest that you consult a dermatologist. Your treating dermatologist might also choose to prescribe you a short course of oral steroids for a week. regards