Dear patient You are suffering from ankylosing spondylitis. HLAB27 means human leukocyte antigen b27 which is positive in patients with ankylosing spondylitis. This disease is heriditary and progressive. It initially involves both sacroiliac joints and lower back then progresses over years to involve whole spine and large joints of body. At the onset you will have lower back pain more in morning with stiffness. Prognosis is not good and at the end there is fusion of all spine joints. Rib cage joints such as costovertebral and costochondral joints are involved and leads to difficulty in respiration. This disease can be controlled with medication and physiotherapy. Start tab hydroxy chloroquine 250mg twice a day with tab sulfasalazine 500mg twice a day for one month. Start range of motion exercises for back and hip and knee joints. Visit expert rheumatologist nearby you for more help. All the best.