Good morning I am sorry to hear about her ill health She is suffering from hepatitis Lethargy and tired ness are common symptoms for hepatitis. The red signals in hepatitis would be drowsiness and bleeding which CGH needs immediate visit to er I would like to suggest few things This medicine valtrex is used for treatment of herpes infection and is rarely a cause of symptomatic jaundice and hepatitis On the way round, herpes infection could be a more likely cause of hepatitis in her situation If I was her treating doctor, I would rather seriously consider herpes hepatitis and investigate and treat which includes continuing valtrex I would suggest you visit an infectious disease specialist and hepatologist for further care Hope this would answer your question Wish her a speedy recovery