I am 39 years old. Healthy. Developed uncontrollable hives for the past four weeks. I have been to my PCP twice and a dermatologist. I have taken an extensive high dose of oral prednisone that relieved hives for a few days but now they are back with a vengeance. I have used Benadryl, Pepcid, Allegra, Claritin, doxepin and hydroxyz, along with prescription creams. Nothing is working. The hives are now all over my body and I am starting to bruise in several areas of my body. I don t know what to do. My mom had hoshimotos and thyroid cancer. That is all for family health related issues.