My PSA has risen from 1.5 to 6 in 3 months. I have had an enlarged prostate (digital and ultrasound screening) for 2 years. The only significant history is HCV genotype 1a which was resolved with Harvoni two years ago and an ex-smoker (5 years free). Ancillary to HCV, I had cryoglobulinemia, thrombocytopenia, RA, and rashes etc. All have returned to normal or dissappeared but I have not yet returned to a normal state. My body is still adjusting. I have ED in which I cannot maintain an erection during intercourse. I take viagra for this. I have just been put on a sulfa drug prior to retesting my PSA. Should a biopsy be necessary, what is the probability of worse ED? Can this be corrected. I also cannot ejaculate except into my bladder. Is this correctable? If my prostate is removed, I ask the same questions as above. I also have COPD. I have found that 3L of O2 during intimacy greatly improves a satisfactory outcome for me. I have read of a hepato-pulmonary syndrome and a hepato-pulmonary-gastro syndrome. Could my current problems be a result of my body trying to return to normal after 49 years of HCV and liver damage? I am 67 and was a triage specialist in the service of the US Army Medical Corps attached to the 101st Airborn in 1969. I was very atletic and still run 3 miles a day with O2 strapped to my back. My pulmonologist has asked me to exercise 30 min/day. I work out with cardio/weights one hour/day. Consequently my weight has risen from 170 to 180 in 3 months. I have had an ongoing love affair with my wife of four years. My previous wife died of lung canter in 2012. We were married before I left for Hua. I/we have been very sexually active and would miss this integral part of my life. Thanks, Dave Shrout