Hello, Thank you for asking t HCM. I went through your history and would like to make suggestions for your mother as follows: 1. Regarding your main query, montelukast 10 mg is usually considered very safe for long term use. Common side effects are nausea or stomach upset. If she is not experiencing such side effects, I would suggest her to continue it as it helps to control her asthma. 2. However, salbutamol inhaler is a rescue type of inhaler, which should be used only for asthma symptoms like wheezing or shortness of breath. If she needs to use it 3-4 time daily, it means her asthma is not well controlled and she needs to upgrade her controller medications. 3. Her controller medications are - montelukast and Seretide 50/250. So I would suggest her to upgrade dose of Fluticasone component of Seretide after consulting her doctor as daily use of salbutamol inhaler is not desirable. 4. I would also suggest you to make sure that the technique of using Accuhaler by your mother is perfect. If it is not perfect, there are chances that adequate amounts of drug might not be reaching to lungs. So please get her technique reviewed by her doctor. 5. I would also suggest your mother regular breathing exercise and a healthy diet which will improve her lung capacity and immunity respectively. Hope above suggestions will be helpful to you and solves your query. Should you have any further query, please feel free to ask at HCM. Wish your mother the best of the health ahead. Thank you & Regards.