Hello, I would like to tell you that Saphris is an antipsychotic which was launched with the claims that it caused minimal metabolic syndrome as compared to olanzapine. And there have been mixed reports regarding that. However in clinical practice we usually see patients complaining of weight gain with this drug and eventually developing metabolic syndrome. Cymbalta is a serotonin nor-epinephrine re-uptake inhibitor (SNRI). This class of drugs are not recommended as antidepressants in bipolar depression as they can cause a manic switch. However, Wellbutrin (Bupropion) is an antidepressant which cause least manic switches when compared to other antidepressants. Therefore its a better antidepressant and is preferred over others in bipolar depression. Its initial dose would be 150mg every morning. It can be increased or maintained depending upon response. However a cover of mood stabiliser (like divalproex) is still recommended. Thanks.