Hello, Welcome to healthcare magic. I understand from your query that your baby has been diagnosed with a diaper rash which is not resolving. You have not mentioned the age of your child. However, with your history and description, I would consider the possibility of Candidiasis. However, it is also important to rule out other rashes which occur in the diaper area like contact dermatitis to diaper itself and an entity called acrodermatitis enteropathica. Candidiasis is a fungal infection commonly occuring in babies in the diaper area. It can be treated with an antifungal like 2% ketoconazole cream applied twice a day. It is very important to keep the area as dry as possible as moisture favours the growth of this fungus. Contact dermatitis to diaper is an allergy to the diaper material. It is mainly confined to the round (convex) areas of the groin where diaper is in close contact with the skin. Use a barrier cream containing zinc oxide every time you change the diaper. Apply generously on the areas where diaper touches the skin. Acrodermatitis enteropathica is a condition which is seen at the period of weaning and is due to zinc deficiency. Zinc levels should be checked in the blood for confirmation. The alternate option is to ask me a direct query by clicking on this short url http://bit.ly/dr-j-chacko , where you have an option of uploading a picture of the lesion which will help a great deal in diagnosing the condition. Hope this helped you. Take care.