Hi, Thanks for writing in. Sorry to know about your wife who is suffering from cancer head of pancreas. Cancer is a challenging condition to treat and we must try to treat it as much possible and at the same time providing pain relief and avoiding discomfort to the patient. It appears that her general condition is slightly below normal and she can be helped with improvement in her diet. It is usual for patients not to have an appetite and in that case please provide her foods that she likes and will help in weight gain. Once general condition improves then doctors might be in a position to give chemotherapy. For the pain you must discuss with a pain management team and they can suggest powerful pain relief medicines to be taken when the pain is more. She does not need to take the medicines all the time but can take certain medicines like opioids when the pain is severe. Please do not worry.