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Suffering from viral hepatitis. Elevated bilirubin levels and stable SGPT levels. Why?

My daughter is suffering from viral hepatitis . As of today her Bilirubin level was 2.8 the same level as on 30 July. While SGPT as of today is 92 compared to 201 as of 30 July. My querry is as to why the S.B. level has not come dowm as compared to SGPT? My daughter s liver function test of 30.07.2012 reads as: Serum Bilirubin (DMSO Method) Total- 2.8; Direct- 2; Indirect - 0.8 SGPT- 206.8 IN THE REVIEW TEST DONE TODAY (05.08.2012) The report reads: Serum Bilirubin: Total - 2.8; Direct- 1.5; Indirect - 1.3 SGPT- 92.5 My worry is when SGPT level has come down why Bilirubin has not come down proportionately.
Asked On : Wed, 8 Aug 2012
Answers:  2 Views:  196
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Nephrologist 's  Response

Thanks for the query

Raised bilirubin signifies liver cell dysfunction. It will take 4-6 weeks in some cases to show little improvement in bilirubin. It might take longer in cases of Hepatitis B and Hepatitis C. Please approach a gastro enterologist for further management.

Avoid the following things

1. High fat and protein diet
2. Heavy exercise

Let her drink lots of water and let her take adequate bed rest.

I wish her a speedy recovery

Answered: Wed, 8 Aug 2012
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General & Family Physician Dr. Chandra Shekhar Sharma's  Response

Welcome to HCM,

Thanks for trusting Healthcaremagic and posting your query.

SGPT is a marker of hepatic inflammation.

SGPT decreased due to decrease in hepatic inflammation.

Due to decrease in hepatic inflammation, excretion of conjugated bilirubin has also improved, thus direct bilirubin level has decreased.

Total bilirubin of your daughter is same, because indirect bilirubin has increased.

Hepatocytes convert unconjugated(indirect) bilirubin into soluble conjugated(direct) bilirubin and then it is excreted.

Due to inflammation hepatocytes were not able to convert unconjugated into conjugated bilirubin, thus your daughter's indirect bilirubin has increased.

As the functioning of liver cells improve, your indirect bilirubin will also decrease and your daughter's total bilirubin will decrease.

Hope you found my response to your query informative and helpful.

If you have further concerns in this regard, you can submit those with Healthcaremagic as well.

With good wishes,
Answered: Wed, 8 Aug 2012
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