Dear Mr Mehra,
If your skin comes up in hives or circular red itchy lesions (with central clearing) that disappears on its own or after medications (usually antihistamines) in a few hours, you are most likely suffering from a condition called urticaria
. This can also manifest with swelling under the skin or swelling on lips and tongue called angioedema
. This is due to histamine release that may be spontaneous or a secondary trigger like scratching (physical), cold or heat (temperature change) or related to hormonal imbalance.
Conditions such as diabetes
, underactive thyroid, or other autoimmune diseases make it worse when they are uncontrolled and a proportion of patients with urticaria have 'autoimmune urticaria' while in others it may be idiopathic.
High-dose long-acting antihistamines for 3 months (minimum duration) may provide extended relief when stopped but may need to be continued for longer. Fexofenadine
180mg and cetirizine
10mg twice daily is the usual choice.