There are many side effects of sulfasalazine
due to long term use
Severe allergic reactions (rash; hives; itching; difficulty breathing
or swallowing; tightness in the chest;
swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness
bloody diarrhea; bluish discoloration of the skin or nails;
chest pain; decreased urination; fever, chills, or sore throat; hearing loss; mental or mood changes; muscle pain; numbness or tingling in the fingers or toes;
seizures; severe or persistent dizziness
, headache, or trouble sleeping; severe or persistent stomach pain; shortness of breath;
swelling or soreness of the mouth or tongue; swollen glands;
symptoms of liver problems (eg, yellowing if the skin or eyes, dark urine, pale stools, severe or persistent nausea or vomiting, persistent loss of appetite);
trouble walking; unusual bruising or bleeding; unusual tiredness or weakness; unusually pale skin.
Hope this answers your query. If you have additional questions or follow up queries then please do not hesitate in writing to us. I will be happy to answer your queries.
Wishing you good health.