Hello Doctor , My mother is suffering frm Severe depresion frm last 4 years, while taking medicines she become absolutely well in between years, but she caught up with this again , and this time the medicines that used to work earlier are not giving satisfacotry results, plz advice us wht shud we do......? her age is 52. she is a widow, she had recently lost her younger brother with the almost same disease, but she was well after his death , suddenly after 3 months she caught up with this again, plz suggest some effective treatment ........