at high doses given for 2 years or more causes retinal deposits, reduced visual acuity & cataracts
in some patients. Anabrez (Anastrazole) is Aromatase inhibitor
is used in the management of ER positive early stage and advanced breast cancer
. It blocks aromatase enzyme & prevents the conversion of androgen to estrogen. More effective than Tamoxifen in early stage in preventing tumor recurrence & in late metastatic stage in preventing tumor progression. Results in lower incidence of side effects like vaginal bleeding, vaginal discharge
, hotflushes & thromboembolic manifestations when compared with Tamoxifen. But it is associated with higher incidence of side effects like fractures & musculoskeletal disorders compared to Tamoxifen.