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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Should Nicotine Lozenges Be Stored At A Particular Temperature?

I am currently trying to quite smoking. I work in an area where I can not smoke at work. But I have a 20 mile drive to and from work. I see on the box of nicotine lozenge that they need to be stored between 68-77 degrees F. My question is, is that necessary or a recommendation?
Mon, 6 Jul 2015
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Addiction Medicine Specialist,  's  Response
More a recommendation. Two components... the lozenge and the nicotine. The lozenge is definitely not stable at melting temperatures (100+). Nicotine is perhaps more stable BUT
The expiration date on the package is measured by taking the package and putting it at an elevated temperature to accelerate the aging process. To qualify for a 1 year expiration date, the manufacturer has strict guidelines in testing and package instructions. It's not so much that it will break down at 95 degree in 3 hrs, but that it WILL break down at 95 degrees in under one year.
The rule of thumb is doubling of aging for every 10 degrees. So... 85 not so bad BUT, not 100 degrees, not near its expiration date (if it is already expired, the heat makes that worse if it is very close to expiration, AND exposed to very hot... worse).
Oh, it might not mention direct heavy sunlight, but that is much worse to the chemicals than heat. Generally it is hard to get the chemical directly into the sun, but the chemicals interact with UV light.
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Should Nicotine Lozenges Be Stored At A Particular Temperature?

More a recommendation. Two components... the lozenge and the nicotine. The lozenge is definitely not stable at melting temperatures (100+). Nicotine is perhaps more stable BUT The expiration date on the package is measured by taking the package and putting it at an elevated temperature to accelerate the aging process. To qualify for a 1 year expiration date, the manufacturer has strict guidelines in testing and package instructions. It s not so much that it will break down at 95 degree in 3 hrs, but that it WILL break down at 95 degrees in under one year. The rule of thumb is doubling of aging for every 10 degrees. So... 85 not so bad BUT, not 100 degrees, not near its expiration date (if it is already expired, the heat makes that worse if it is very close to expiration, AND exposed to very hot... worse). Oh, it might not mention direct heavy sunlight, but that is much worse to the chemicals than heat. Generally it is hard to get the chemical directly into the sun, but the chemicals interact with UV light.