Hi, thanks for writing to HCM.
taken over a prolonged period of time tend to produce serious systemic adverse reactions. The most common of all the side effects is Renal damage, also termed as ANALGESIC NEPHROPATHY.
So, it is not advisable to use a single medication for longer periods. Instead, either taking a lesser dose of same medication or shifting to a different analgesic medication tends to lower the chances of adverse reactions.
Hope this information is helpful. Good day