Hello and welcome to HCM,
The symptoms of fever, tiredness, easy bruising, breathlessness and decreased appetite indicate anemia, low platelet counts, and constitutional symptoms of chronic illness (e.g. cancer).
However, there are other causes of bone marrow suppression like granulomatous infections/ inflammations, infection with parasites like malaria, leishmaniasis
, fibrosis, previous radiation exposure, etc.
Bone marrow suppression can also occur due to radiation exposure.
Consult your hematologist
for relevant investigations which includes complete blood examination, bone marrow aspiration, bone marrow biopsy, etc. to come to exact diagnosis.
Positive HLA B27 suggests ankylosing spondylitis
. It is an autoimmune disease
process which damages the joints of the spine.
You need to consult a rheumatologist
for management of the disease process.
Thanks and take care
Dr Shailja P Wahal