Hi Kuldeep arora.
Thanks for coming to HCM.
Tubercular treatment in pregnancy is safe and constitutes combination of isoniazide, rifampicin
for two months followed by isoniazide and rifampicin for next four months. Drug induced hepatitis
(raised liver enzymes i.e ALT/AST and serum bilirubin
) is known complication of Anti tubercular drugs especially isoniazide, rifampicin and pyrazinamide.
Once hepatitis develops ( as raised ALT told by you), the treatment has to be stopped till the enzyme level comes to normal value and then the abovesaid three culprit drugs are introduced one by one. Liver function has to be checked after 7-10 days of introduction of the drug each time and culprit drug is identified and discontinued. Further treatment is then continued with modified regimen.
In your wife's case the pattern of rising ALT is such that it rises when therapy is given and decreases once it is withdrawn, so it's a clear case of drug induced hepatitis and has to be managed as stated above.
Consult your doctor for the same....