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Saphris or asenapine is a newer drug and it is very useful in psychosis and bipolar disorder
. Cymbalata is duloxetine and is used in depression, anxiety and fibromyalgia
When ever any drug like duloxetine is started a rebound increase in anxiety occurs along with irritability. But these side effects go after 1-2 weeks.
Your complaints like paranoid, irritability etc. may occur with asenapine as during initial phase of therapy with antipsychotic
drug, subjective and objective restlessness
, irritability occur, which is also called akathesia. Although this type of side effect is common with typical older antipsychotic drugs and newer drugs are devoid of such type of side effects. Still there is a risk and we can assume that the symptoms are due to asenapine. I advise you to visit your psychiatrist
and take opinion regarding the problem. Proper dose adjustments will help.
Dr. Seikhoo Bishnoi