Hi, Welcome to HCM, Patients suffering with Poly cystic ovarian disease have multiple small cysts in their ovaries. Thus ovaries become enlarged and produce excessive amount of estrogen and androgen hormones. This prevents ovulation and absence of ovulation causes infertility. Many patients with PCOD also have insulin resistance and have raised level of insulin. These patients may not respond to clomiphen, thus treated with anti diabetic drugs like metformin and troglitazone. You are already taking Glycomet (Metformin). In these patients, Clomiphen is used to stimulate ovulation. Low doses of dexamethasone can also be given simultaneously to suppress androgen production from adrenal gland. If clomiphen doesn t work, a new anti-estrogen called Letrozole can be given. Clomifen resistant women suffering with PCOD, may need HMG(gonadotrophis) to induce ovulation. Difficult patients may require a combination of GnRH analog and HMG to induce ovulation successfully. Metformin can improve your fertility by reversing endocrine abnormality and improving your ovulatory response. You can conceive, provided ovulation occurs and you have sex around ovulation day. Thanks for your trust in Healthcaremagic and posting your query. Hope you found my response to your query informative and helpful. With good wishes, Dr.Chandra Shekhar Sharma