Sign-in to Ask A Doctor - 24x7
OR
Sign in with GoogleGet your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
On BP Medicines, Has Decrease In GFR Over The Months. Reason?
Hello My husbands GFR is at 70. Last year in Febuary at his annual physical (this time a year ago) his GFR was 93. His blood pressure was high thus his physician started him on Losortran. After 6 months his GFR when down to 76 and had microalb showing in his urine . (he is diabetic) I understand under certain circumstances ACE inhibitors can cause kidney problems. I am concerned as his GFR has never been a problem. He is 58 years old.
Mon, 4 Feb 2013
Hello,
Clinical studies have shown ACE inhibitors reduce the progress of diabetic nephropathy independently from their blood pressure-lowering effect. This action of ACE inhibitors is used in the prevention of diabetic renal failure.However since ACE inhibitors can cause some renal impairment,it is used with caution in patients with impaired renal function.
You should keep giving LOSARTAN ,for reduction of blood pressure,as it delays the progression of diabetic nephropathy which your husband seems to be suffering from.
Besides this he should take other precautions like avoiding nephrotoxic drugs like gentamicin and pain killers.
Keep a tight control of blood pressure and blood sugar levels.Your aim should be to delay the progression towards ESRD ( end stage renal disease ),as that would be the stage when only kidney transplant is the ultimate treatment.
Keep a regular date with your diabetologist as well as nephrologist.
Thanks
Clinical studies have shown ACE inhibitors reduce the progress of diabetic nephropathy independently from their blood pressure-lowering effect. This action of ACE inhibitors is used in the prevention of diabetic renal failure.However since ACE inhibitors can cause some renal impairment,it is used with caution in patients with impaired renal function.
You should keep giving LOSARTAN ,for reduction of blood pressure,as it delays the progression of diabetic nephropathy which your husband seems to be suffering from.
Besides this he should take other precautions like avoiding nephrotoxic drugs like gentamicin and pain killers.
Keep a tight control of blood pressure and blood sugar levels.Your aim should be to delay the progression towards ESRD ( end stage renal disease ),as that would be the stage when only kidney transplant is the ultimate treatment.
Keep a regular date with your diabetologist as well as nephrologist.
Thanks
I find this answer helpful
3 Doctors agree with this answer
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer.
For a more detailed, immediate answer, try our premium service
[Sample answer]
Related questions you may be interested in
Recent questions on Kidney transplantation
Loading Online Doctors....