Clinical studies have shown ACE inhibitors reduce the progress of diabetic nephropathy
independently from their blood pressure-lowering effect. This action of ACE inhibitors is used in the prevention of diabetic renal failure
.However since ACE inhibitors can cause some renal impairment,it is used with caution in patients with impaired renal function.
You should keep giving LOSARTAN ,for reduction of blood pressure,as it delays the progression of diabetic nephropathy which your husband seems to be suffering from.
Besides this he should take other precautions like avoiding nephrotoxic drugs like gentamicin and pain killers.
Keep a tight control of blood pressure and blood sugar levels.Your aim should be to delay the progression towards ESRD ( end stage renal disease ),as that would be the stage when only kidney transplant
is the ultimate treatment.
Keep a regular date with your diabetologist
as well as nephrologist