Dear patient, Thanks for your health concerns. Indeed, some of the quinolones, particularly gatifloxacin, have been associated with peripheral neuropathy, although usually transient. It is in the differential diagnosis but also other metabolic/ systemic causes are possible for a peripheral neuropathy, including diabetes and B12 deficiency, both which can have fatigue as part of the presentation. Very very rare, but thiamine deficiency, also known as beri-beri, can give both CHF and neuropathy. Amyloidosis is another cause of CHF and neuropathy. I would encourage you to consult a provider, specifically a neurologist, who would be able to conduct an initial basic workup for neuropathy Yours truly, Dr Brenes-Salazar MD Cardiology Mayo Clinic MN