These are the few suggestions if all the medical causes are ruled out in your case. Detergent-laden soaps are drying to the skin, so try a milder version. Also, a gentle exfoliation (technique aimed at removing dead skin cells from the face and body) twice a week helps scrub away dry, dead cells so your hands feel smoother. Go for specially formulated hand creams, and use hand cream more than once a day. Drink lots of water, and consider using a humidifier in your home if the air is dry. Once a week, treat your hands to a super-moisturizing treatment: Soak hands in hot water with a few tablespoons of baking soda for half an hour, next, dry hands and cover them with a heavy hand cream. Put the hands in plastic bags inside old socks for 20 minutes. Another option is paraffin wax treatments, which work on the same principle.