It is really glad to know that your father is doing very well despite having metastatic prostate cancer
for this long.
He has been on complete androgen blockade till now. A rising PSA is now suggestive of a progressive disease, probably becoming castration resistant.
Intermittent hormone therapy
is not an option in your father as he has undergone orchiectomy.
He will need to stop taking his bicalutamide
medications NOW as they are not working on his disease. we could wait for 4 to 6 weeks and repeat a PSA to see if it falls or remains stable.
in case PSA remains stable, he could be placed on a close follow up with 6 weekly PSA evaluations until such time his PSA increases.
5-ARI inhibitors could be tried in the interim. they may not be very beneficial in such a long standing metastatic disease but they will not harm him either.
An increase in PSA alone will not stand as the basis for his subsequent treatment. we need to closely look at his pre-treatment PSA levels, rapidity with which his PSA is rising (PSA Doubling time) his overall disease burden, general health (anemia, low protien levels, for instance) and his symptoms to decide when to institute next therapy.
there are many second line hormonal agents available including Honvan(Fosfesterol), Ketoconazole
, Estramustine and the newly introduced Abiraterone
, all of which are oral medications and confer disease control for variable periods of time (from months to years).
All these drugs will eventually fail to control the disease and your father could subsequently be considered for chemotherapy
if need be.
He could in the meantime keep himself healthy with regular brisk walks, gentle joint and spine strengthening exercises, meditation
and low meat, high fiber diet which will make him fell well and has now proven to delay prostate cancer disease progression.
With the kind of disease behavior he has shown, i am sure he will do very well for many more years to come. a guarded approach is needed in him before therapeutic manipulations are made which you could well consider after a detailed discussion with your treating doctor.