No, I think you are not overly concerned. Your husband is a young patient (46 years old) with a recent history of significant weight loss
(without a diet to loose weight), with anemia
and a lump in the throat. He should have a complete evaluation: He should be observed urgently by a physician, with a complete blood analysis (CBC and chemistry) and probably he should do a CT scan
to detect possible lesions, which can explain these symptoms. Hope this answer was helpful.