Hi.. Thanks for the query In certain people , cold sores or herpes simplex infection tends to be very recurrent.therapy is effective when started within 48 hrs of therapy. The common medications used are Acyclovir , Valacyclovir. Recurrence is reduced by the therapy given in between attacks monthly for a few days. It is common to have a superimposed bacterial infection on the lesions .topical anti biotic creams can be applied to reduce them. You can consult a dermatologist to get a prescriptions for continuous prophylaxis .Now you can start application of anti biotic creams like Fusidic acid or Mupirocin to reduce superimposed bacterial infections. Hope this helps. Take care!