Thank you for your query. I understand your concern. Hypothyroidism may have different etiologies. It can also be primary (problem with the thyroid gland) or secondary (problem due to the pituitary glad which is responsible for stimulating the thyroid gland) If the cause is an autoimmune disorder (hashimoto s disease) or a tumor that causes destruction of the thyroid tissue - the condition is permanent and needs lifelong supplemental of synthetic or natural thyroid hormone. If on the other hand it is due to nutritional deficiencies (like iodine deficiency), this can be corrected by treating the deficiency ( you would still need to take thyroxine supplements till it gets corrected) If your TSH is in the normal range, it means that your thyroid is still being stimulated by the pituitary to produce hormones. If it is too low, then you will need to reduce your dosage till the TSH comes upto normal range. Ideally the lowest possible dosage to maintain TSH within normal levels without associated symptoms will be ideal. You could reduce your dosage gradually, instead of halving it. Thyroxine is important for most functions in your body. sudden fluctuations or deficient levels will disrupt this. Take 88mcg for 6 weeks. Repeat your TSH, Free T3, T4 & see how it is. If all are withing normal values but TSH shows slight rise, continue at 88mcg for another 6 weeks. A steady TSH shows that you are ok. you may reduce it further to 75 mcg and repeat the process. If , however , it shows an increase, do not reduce the dose further and monitor TSH every 2 months. If it goes above the normal range, time to go back to 100 mcg. thereafter, monitor every 6 months. I would also do an Antibody test to check for auto immune disorder of the thyroid. Sometimes, the proteins that bind to the thyroxine can be deficient as well. This can also lead to high TSH levels. What were your initial Free T3/T4 levels like? There is no benefit to a lower dosage , in terms of effects on the body. The dose must be effective and the minimum that is required to maintain TSH at normal levels should be administered and maintained. Please note that if you are trying for a baby, it is important to have normal thyroid hormone levels for conceiving and for a normal pregnancy. The thyroxine requirements will increase in pregnancy and will be monitored closely. If it helps, I am a hypothyroid and am on levothyroxine myself :-). Please let me know if this has been helpful. Wish you good health and please get back to us if you need further clarifications