You are taking four medicines – olmesartan, amlodipine, lisinopril and carvedilol. For control of blood pressure (BP), initially one drug is prescribed. If one drug does not control BP effectively, then a combination of two, three, and four drugs depending upon control of BP, is prescribed. You have high BP since a long time. High BP causes lots of complication such increased thickening of heart muscle (left ventricular hypertrophy) due to high pressure and kidney disorder such as loss of precious protein especially in long standing high BP . These drugs not only control high blood pressure but also prevent and cure complications of high BP. As for example, lisinopril prevents thickening of heart muscle and prevents loss of protein from kidney. Combination of four drugs has synergistic effects. That means, these drugs complement each other’s effect and prevents development of each other’s side effects. For example, carvedilol (Coreg) prevents tachycardia (high heart rate) caused by amlodipine (Norvasc). So in brief, you need a combination of drugs for effective control of BP and prevention of complications of high BP. You always have the option of taking a second and even third opinion if you are not satisfied with treatment. Advice 1. Continue all medicines and do not alter dose or drug unless advised by your doctor 2. Take second opinion with a cardiologist for review of treatment 3. Regular exercise at least 30 minutes for 5 days in a week. The best types of exercise for lowering BP are walking, jogging, cycling, swimming and dancing 4. Eating a diet that is rich in whole grains, fruits, vegetables and low-fat dairy products and skimps on saturated fat and cholesterol 5. Consume less salt 6. Avoid smoking, alcohol, coffee and caffeinated beverages 7. Lose extra weight if you are overweight and keep your body mass index between 19 and 25. BMI is calculated by formula BMI = Weight in Kilograms / (height in meters x height in meters) 8. Reduce your metal stress because stress activates sympathetic system and increases BP 9. Measure your BP regularly and be in touch with your doctor I hope this information will help you. I will be happy if you ask another question Thanks