Thank you for your query.
Almost 162 medications are known to cause drug interactions with Depo provera.
Vitamin B12 (cyanocobalamin)
Vitamin D3 (cholecalciferol
These are not common medications, and very few antibiotics affect efficiency of Depo provera, only griseofulvin
and HIV medications are known to do so.
A drug that speeds up metabolism would lead to rapid metabolization of Depo , and theoretically lessen its duration of action.
Discuss this with your healthcare provider next time.