HealthCareMagic is now Ask A Doctor - 24x7 | https://www.askadoctor24x7.com

Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
159 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Is There Any Concern If Methotrexate Is Taken With Augmentin For UTI?

I have a uti and my general practitioner has me on augmentin. I take 15 mg of methotrexate per week for ra. My rheumatologist said to stop the methotrexate until uti subsides. Well..... I've already taken my weekly dose of mtx. What's going to happen? I'm worried!!!! YYYY@YYYY
Wed, 4 Dec 2013
Report Abuse
General & Family Physician,  's  Response
I have understood your situation.

Your rheumatologist was right in asking you to stop taking methotrexate(MTX)

First, there is a possibility of drug interaction between MTX and amoxycillin ( one of the constituents of augmentin) as amoxycillin will decrease the excretion of MTX and thus increase its blood level.

In this situation ,you should report to your general practitioner if you have fever,bleeding,sore throat,bruising or weakness.

Secondly,clavulanate the other constituent of augmentin may cause damage to the liver when used along with MTX.If you have jaundice ,rash ,abdominal pain,chills and vomiting be prompt in reporting to your GP and he will assess your liver enzymes to rule out any damage.

My advice to you is that if you experience any of these symptoms report to your physician and stop Methotrexate for the time being as you are on Augmentin.




I find this answer helpful

 1 user finds this helpful
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on
 

Recent questions on Rash


Loading Online Doctors....
Is There Any Concern If Methotrexate Is Taken With Augmentin For UTI?

I have understood your situation. Your rheumatologist was right in asking you to stop taking methotrexate(MTX) First, there is a possibility of drug interaction between MTX and amoxycillin ( one of the constituents of augmentin) as amoxycillin will decrease the excretion of MTX and thus increase its blood level. In this situation ,you should report to your general practitioner if you have fever,bleeding,sore throat,bruising or weakness. Secondly,clavulanate the other constituent of augmentin may cause damage to the liver when used along with MTX.If you have jaundice ,rash ,abdominal pain,chills and vomiting be prompt in reporting to your GP and he will assess your liver enzymes to rule out any damage. My advice to you is that if you experience any of these symptoms report to your physician and stop Methotrexate for the time being as you are on Augmentin.