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Is There An Alternate Medication For R-Cinex 600 For TB?
My wife is suffering from TB of pancrea fr last 7 months. For first 3 months she took r-cinex600 nd other medicine for TB. After 3 months till daate, she is taking R-cinex600, benadon 40 and Zevit. For last 4 months back her legs are having numbness. We met neurologist and he said, this is due to R-cinex600. He initially advised Gabapin for 10 days but since that didn t find any good, he replaced it with some other medicine which was kind of tranquilizer. The doctor who is treating her TB asked us to stop that medicine as it was causing her some sort of depression. We then started taking homeopathic medicine and those medicines reducer the numbness slightly. Now for last a week or so she is a tired all the time, swollen legs and less appetite. Someone told us, this is due to R-cinex600 which is affecting her lever. We don t know what to do. The doctor for recently treating her TB is not taking the case seriously. Please advise if there is any medicine which she can take instead of r-cinex600 which is equally effective without causing any side effects on lever.
Thu, 26 May 2016
Hello there
I understand your conern.
Rifampicin-related adverse reactions (ARs), including hepatitis, cholestasis,
dermatological events and gastrointestinal disturbances, are not rare and
some even require rifampicin discontinuation. If rifampicin cannot be used,
current recommendations suggest a prolonged anti-tuberculosis regimen of
up to 12–18 months,which will be associated with a higher rate of poor
adherence, recurrence and the possible emergence of resistant strains.
Rifabutin, a rifamycin with activity against Mycobacterium tuberculosis, has
been used in patients coinfected with tuberculosis and HIV, as it has fewer
drug–drug interactions than rifampicin. Rifabutin has activity against
mycobacteria similar to that of rifampicin and in fact may be more potent.
Furthermore, rifabutin may have a lower incidence of severe ARs than
rifampicin. Thus, it may be an attractive substitute in situations where
rifampicin is intolerable.
Please consult the doctor treating your wife for the substitution. Her
tiredness and swollen legs could be because of hypoproteinemia.. So please
ask her to take a healthy diet while increasing the protein
Hope that helps your wife
cheers
I understand your conern.
Rifampicin-related adverse reactions (ARs), including hepatitis, cholestasis,
dermatological events and gastrointestinal disturbances, are not rare and
some even require rifampicin discontinuation. If rifampicin cannot be used,
current recommendations suggest a prolonged anti-tuberculosis regimen of
up to 12–18 months,which will be associated with a higher rate of poor
adherence, recurrence and the possible emergence of resistant strains.
Rifabutin, a rifamycin with activity against Mycobacterium tuberculosis, has
been used in patients coinfected with tuberculosis and HIV, as it has fewer
drug–drug interactions than rifampicin. Rifabutin has activity against
mycobacteria similar to that of rifampicin and in fact may be more potent.
Furthermore, rifabutin may have a lower incidence of severe ARs than
rifampicin. Thus, it may be an attractive substitute in situations where
rifampicin is intolerable.
Please consult the doctor treating your wife for the substitution. Her
tiredness and swollen legs could be because of hypoproteinemia.. So please
ask her to take a healthy diet while increasing the protein
Hope that helps your wife
cheers
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