Hi, I just switched from ativan to klonopin 3 weeks ago and am even more depressed than before. I tried effexor and liked it but, I have low bp and high heart rate when I stand POTS syndrome. The effexor makes my hr go up a lot more, 3rd day standing hr was 170. The Dr. Started me out at 150mgs. The only drug I have had luck with has been paxil at 30mgs. Are paxil and Klonopin a good mix? I also read that K decreases seratonin, is this true? If so, should paxil be able to pull me out of the terrible mood I'm in, crying, fearful ect? I'm hoping that the Paxil will kick in and I can start weaning the 1mg I am taking of K. My psych said the Ativan was giving me paridoxical effect after 8 months. I feel the K is doing that too so I want to get off at some point. Thank you!! Brooke