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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Overdosing On Doxepin HCL-100mg Twice As Much A Concern?

hi, I think my friend might have taken to many Doxe-pin HCL 100MG when she went to bed. she normaly takes two. however tonight she claims to have taken five. i have been able to wake her and get her to respond to a few smiple questions. her eye seem to dialate at the same rate. what systems and signs can i monitor to ensure she is ok?
Fri, 9 Dec 2016
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General & Family Physician,  's  Response
Hi & Welcome.

Yes, it can cause harmful effects if taken in larger doses.
She needs to be treated in the hospital immediately.

Doxepin (tricyclic antidepressant) is used to treat anxiety or depression.
Based on the history given your friend seems to have developed toxicity due to overdose of Doxepin.

Overdose of Doxepin can cause excessive drowsiness, confusion, disturbed concentration, transient visual hallucinations, dilated pupils, agitation, hyperactive reflexes, stupor, muscle rigidity, vomiting, hypothermia, hyperpyrexia, constipation, retention of urine, increased heart beats with irregular rhythm, hypertension, etc.

She needs to be taken immediately to the hospital for the management of poisoning which in addition to general support may also need administration of certain drugs such as Physostigmine and Diazepam to overcome the harmful effects of overdose.

Hope this will help her.


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Is Overdosing On Doxepin HCL-100mg Twice As Much A Concern?

Hi & Welcome. Yes, it can cause harmful effects if taken in larger doses. She needs to be treated in the hospital immediately. Doxepin (tricyclic antidepressant) is used to treat anxiety or depression. Based on the history given your friend seems to have developed toxicity due to overdose of Doxepin. Overdose of Doxepin can cause excessive drowsiness, confusion, disturbed concentration, transient visual hallucinations, dilated pupils, agitation, hyperactive reflexes, stupor, muscle rigidity, vomiting, hypothermia, hyperpyrexia, constipation, retention of urine, increased heart beats with irregular rhythm, hypertension, etc. She needs to be taken immediately to the hospital for the management of poisoning which in addition to general support may also need administration of certain drugs such as Physostigmine and Diazepam to overcome the harmful effects of overdose. Hope this will help her.