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Is it safe for a 12 year old epileptic to take Potrate MB6 tablets for avoiding formation of kidney stones ?

My 12 year old daughter is suffering from epilepsy since last 5 years. Since she was not responding to medicines, she has been put on Ketogenic Diet since last 6 months. The treatment, though very difficult to administer, seems to be giving encouraging results. Her diet mainly consists of fat and proteins with very limited quantities of carbohydrates . Her doctor has now advised to give her Potrate MB6 tablets twice a day. This has been done to avoid kidney stone formation. I want to know is it safe to take this drug and is the dosage correct? She has no past history of kidney stones .
Asked On : Thu, 16 Feb 2012
Answers:  2 Views:  282
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General & Family Physician 's  Response
Hello Rajneesh,

Glad to hear your daughter is responding well to the Ketogenic diet. Ketogenic diet is usually offered to children with intractable epilepsy and whose seizures are not controlled with two or three antiepileptic medications. It is also useful in adults and effective in most types of seizures regardless of the age and cause of seizures.

Children on ketogenic diet is given Calcium, Vit D3 supplement and multivitamin. Potassium Citrate is given to reduce the risk of kidney stones.So Potrate MB6 can be continued although she has no past history of kidney stones.Good water intake also reduces risk of kidney stones further. Certain antiepileptic medications like Topiramate and Zonisamide are suspected to increase the risk of kidney stones when used along with the ketogenic diet ,although there is no evidence to prove the same.

Your doctor would also be monitoring your daughters height ,weight and other parameters like complete blood count, fasting lipid profile, carnitine levels, urinalysis, urine calcium, and urine creatinine periodically while on the ketogenic diet.

Like you said the diet can be difficult to stick to despite the significant benifits due to the side effects like diarrhea, constipation, nausea, vomiting, and exacerbation of gastroesophageal reflux which can be tackled with laxatives and other medications.

Some of the other problems may include altered lipid levels, hypoglycemia, hyperuricemia, hypoproteinemia, hypomagnesemia, hyponatremia, hepatitis,kidney stones,Osteopenia, osteoporosis etc. which can all be detected by periodic check up and treatment if they occur.

If there is good seizure control while on the ketogenic diet antiepiletic medications may be attempted to be tapered.Also children showing improvement with the diet is likely to have good outcomes even after stopping the ketogenic diet after achieving seizure free status.

Wishing your daughter a seizure free state soon...

Answered: Fri, 17 Feb 2012
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General & Family Physician Dr. Ramesh M.Vachharajani's  Response
Hi,Thanks for query,
I do not think diet has any relation with Epilepsy,if at all epilepsy is there. there is no alternative other than anti epileptic medicines.
I wonder why kidney stones come in the way of epilepsy unless from investigations he might have stone doubt.
Consult neuro physician and disccuss the she is taking treatment for 5 years,epilepsy might have cured and drugs may be dis continued.
Ok and bye,
Answered: Thu, 16 Feb 2012
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