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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Dangerous To Take High Dose Of Paracetamol?

Hi.... I just had this question because my friend is worried of his life n he,wants to end up.....he is tellin tat I m gonna take 20 paracetemol n,die....i m advicin him not to do.....is 20 paracetemol in a go is dangerous ? Because I ll nt b thr to look aftr him all te time...
Tue, 2 Sep 2014
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General & Family Physician,  's  Response
Thanks for using healthcaremagic.
Brief answer:yes,your friend is nearly correct.
Detailed answer:Normal therapeutic dosage roughly 10-15 mg/kg/dose,maximum tolerable dose 4-6 grams/day if given at 6hrs and 4hrs interval respectively.20 tablets roughly contains above 6grams(if its a 325mg tab) which when taken as single dose,can cause acute fulminant liver failure,and without an antidote called N-acetylcysteine,victim may even end up in coma and death.Hope I have answered your query.If any other questions,happy to answer you.Take care of you and your friend.
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Is It Dangerous To Take High Dose Of Paracetamol?

Thanks for using healthcaremagic. Brief answer:yes,your friend is nearly correct. Detailed answer:Normal therapeutic dosage roughly 10-15 mg/kg/dose,maximum tolerable dose 4-6 grams/day if given at 6hrs and 4hrs interval respectively.20 tablets roughly contains above 6grams(if its a 325mg tab) which when taken as single dose,can cause acute fulminant liver failure,and without an antidote called N-acetylcysteine,victim may even end up in coma and death.Hope I have answered your query.If any other questions,happy to answer you.Take care of you and your friend.