Hello, Welcome to Healthcare Magic. I have read your question fully and understand your concerns. I understand from your question that your wife is taking different medications. She is on Ovaral; I understand it is a combined oral contraceptive pill. If she has been taking the combined oral contraceptive regularly without missing any pills, then she would be protected from an unwanted pregnancy, and she does not need any emergency contraception. In the event that she has not been taking Ovaral regularly and missed a few pills, then she is at risk for pregnancy if you had unprotected sexual intercourse. Even though she is taking the hypothyroid medication, she can still take the emergency contraception. I hope this answer has helped you. Thank you Regards Dr Sunita Sayammagaru