Hello dear Greetings Regarding your diagnosed enlarged spleen by your physician yes this is a cause for concern reason due to possible underlying diseases which are as follows Tropical splenomegaly syndrome Chronic malaria Typhoid fever Liver cirrhosis Splenic vein thrombosis Metastatic tumor In view of this please do the following test Malaria parasite test Widal test Ultrasound Blood culture Meanwhile please see a gastroenterologist specialist for further clinical assessment and adequate drug prescription based on the outcome of the result I hope this helps Regards